Current QIMR Berghofer appointment
- 2018 – current: Group Leader, Organoid Research Laboratory
Other current appointments
- 2017 – 2020: NHMRC Career Development Fellow
- 2017 – 2020: National Heart Foundation Future Leaders Fellow
- 2018 – current: Adjunct Senior Fellow in the Institute for Molecular Bioscience, The University of Queensland
- 2018 – current: Honorary Senior Fellow in the School of Biomedical Sciences, The University of Queensland
- 2014 – 2018: Group Leader, Cardiac Regeneration/Muscle Tissue Engineering Lab, The University of Queensland, Australia
- 2013 – 2016: NHMRC Early Career Research Fellow
- 2011 – 2012: German Cardiology Society Fellow, Wolfram-Hubertus Zimmermann Lab, University Medical Center Göttingen, Germany
Current Area of Research
The power of using human organoids as a model system
The development of in vitro human model systems that more accurately represent in vivo biology has been identified as a key priority area for reducing the failure of clinical trials due to toxicity or lack of efficacy (see Cook et al., Nature Reviews Drug Discovery, 2014 and Horvath et al., Nature Reviews Drug Discovery, 2016). My program of research aims to establish new technologies to provide more accurate models of human disease.
Heart disease therapeutics
There are ~23 million heart failure patients worldwide, which has an enormous socio-economic impact. In Australia, there are over 300,000 heart failure patients, which costs the Australian economy around $1 billion per year; half of these patients will die within 5 years of diagnosis. There is currently no cure for heart failure and treatments only slow disease progression. Therefore, we are screening for therapeutics in human cardiac organoids to transform and revolutionise the treatment of heart failure and thereby reduce the socio-economic burden of cardiovascular disease.
Research in Cardiac Organoids
Extending previous research to utilise human cardiac organoids to the influence of factors that are difficult to dissect in vivo and discover processes that we can target for the treatment of cardiac disease.
- Development of new cardiac organoid technologies to understand cellular interactions both between cardiac cell types and also with other tissues.
- How metabolism and metabolites directly impact human cardiac biology.
- Finding new regulators of cardiovascular biology to discover new therapeutic targets.
James also wishes to extend his research program to other organoid types in the future and use the same approaches to unlock the biological complexities of those organs using similar approaches that have been used for the heart tissue.
Human cardiac organoid development
James Hudson’s previous research has led to the development of human cardiac organoids that provide a representation of human heart tissue in a dish. Additionally, this has led to the discovery of biological processes regulating cardiac biology:
- The complex combinatorial signalling that drives mesodermal and cardiac specification from human pluripotent stem cells (hPSCs);
- Multiple cell populations are essential to create functional heart tissue and non-myocyte population phenotype has a big influence on the tissue properties;
- Mechanical loading (both static and dynamic) is a very important factor and has a big influence on the tissue properties;
- Metabolic conditions strongly influence tissue phenotype and function.
- Australian Physiological Society
- American Heart Association
- International Society for Stem Cell Research
- International Society for Heart Research
- 2017: Centenary Institute Medical Innovation Award
- 2017: National Heart Foundation Queensland Cardiovascular Researcher of the year
- 2017: NHMRC Career Development Fellowship
- 2017: National Heart Foundation Future Leaders Fellowship
- 2016: The National Heart Foundation Paul Korner Innovation Award
- 2014: NHMRC awarded outstanding nominated assessor
- 2013: Best oral presentation Australasian Society for Stem Cell Research
- 2013: NHMRC Early Career Research Fellowship
- 2011: German Cardiology Society Postdoctoral Fellowship
- 2007: Student Winner, UniQuest Trailblazer
- 2006 Bachelor of Engineering (Chemical and Biological), The University of Queensland, Australia
- 2011 PhD (Biotechnology), The University of Queensland, Australia