- Suitable for PhD, Honours, or Masters students
Multiple myeloma is a type of blood cancer that grows in the bone marrow (BM). Myeloma progression is tightly associated with destruction of the normal BM architecture and remodelling. We hypothesize that sterile inflammation triggered by tissue-injury and cellular damage has a prominent impact on myeloma immunopathology. Indeed, we have recently showed that a certain type of inflammatory component and its downstream pro-inflammatory cytokine critically drives myeloma progression by generating an immunosuppressive BM niche (Nakamura et al. Cancer Cell 2018). Now we wish 1) to obtain an in-depth understanding of the vicious cycle of inflammation and immunosuppression in the BM milieu, and 2) to design the optimal anti-myeloma therapy by targeting several candidate inflammatory signalling pathways in preclinical mouse myeloma models. In recent clinical trials, immunotherapies have shown promising results in patients with multiple myeloma. This project will provide important translational implications for next generation of anti-myeloma therapies.
In the proposed project, the student will learn following research techniques: 1) in vivo murine models (various drug treatments, bioluminescence imaging), 2) in vitro cell culture (T cell stimulation assays, macrophage activation assays, 3) flow cytometry analysis, and 4) immunoblot analysis.