Neutrophils are the most abundant immune cells in humans and are thought to promote tumour progression and therapy resistance. However, the underlying cellular and molecular mechanisms are incompletely understood. We have recently, identified a novel target to inhibit neutrophil migration into tumours and the tumour draining lymph node, thus improving cancer immunotherapy. We have unravelled phenotypic plasticity of neutrophils as a key regulator of immune suppression. This project aims to elucidate where neutrophils interact with and how they suppress T cells using mouse reporter strains and intra-vital imaging techniques as well as RNA-sequencing and multi-parameter flow cytometry. Moreover, we want to identify signalling cues that modulate the phenotypic plasticity of neutrophils.
The project will concern research work in an international team of highly motivated scientists in the areas of cellular and molecular immunology, cancer cell biology, and microscopy in both experimental mouse models and human patient material. Theoretical training in immunology is highly desirable. A substantial interest in microscopy and imaging techniques is required. Technical skills in animal experimentation, flow cytometry and/or cellular immunology are preferable.
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