High-mobility group box 1 (HMGB1) and interleukin-33 are constitutively expressed in the nucleus. However, both proteins can translocate to the cytoplasm and if released into the extracellular environment, act as cytokines to induce functional responses in local cells. The processes that regulate the release of these two proteins (also described as ‘alarmins’) remains poorly described, however we have recently identified a role for the purinergic receptor P2RY13, and a recently described form of programmed cell death termed necroptosis. This project will interrogate the role of these two pathways in regulating alarmin release using experimental mouse models and in vitro culture models of primary airway epithelial cells.
Associate Professor Simon Phipps | email@example.com