- This project is suitable for a PhD student
To support our hypothesis that unlike the Western lifestyle, parasites, such as hookworms, modulate maternal microbiome and promote infant bacterial colonization with key bacterial species that are critical for immune tolerance, we will perform a comparison study between a mother and baby cohort located in Papua New Guinea (PNG)) and Brisbane (QLD). This project seeks to examine infant microbiome colonisation via BM and enrol pregnant women to perform a longitudinal microbiome study of the child through the first year of life.
Project description: BM and stool from both mother and baby will be collected at 1 month post-partum, and from the child at 6 month and 12 month of age. Socio-health and dietary details will be collected at the time of recruitment and at each sample collection time point. Faecal samples from PNG will be further screened to determine the presence and burden of soil-transmitted helminths (STH). Faecal and BM samples from both locations will be analysed two-ways for microbial sequencing (16S rRNA) and metabolite content by nuclear magnetic resonance spectrometry.
This project relies heavily on the use of bioinformatics.