- Some components of this project are suitable for Honours students, flexible for clinical students and entire project is suitable for PhD students.
Research Area: NK cells, Innate lymphoid cells, Angiogenesis, Metastasis;
Phenotypic plasticity means that cells are able to quickly respond to environmental changes by losing and gaining properties. Myeloid immune cells including dendritic cells, macrophages, monocytes and granulocytes are known to be highly plastic. This concept is best described in macrophages. Macrophages can acquire a so called M1 (anti-tumour) or M2 (pro-tumour) phenotype in the context of cancer. We believe that neutrophils are as plastic as macrophages. However, signalling pathways modulating the phenotype of neutrophils are unknown. We have generated genetically modified mice in which signalling components of the TGF-beta pathway are deleted specifically in neutrophils. Using these mice and disease models for cancer and infectious diseases we will study neutrophil plasticity. In this project you will learn how to plan and conduct animal experiments, multi-colour flow cytometry, RNA-sequencing and various cell culture assays.