- Suitable for Honours students
The brain comprises an intricate architecture of neurons and blood vessels, with normal brain function relying heavily on the physical properties of these entities. In particular, structural damages in blood vessels have been shown to be related to cognitive impairments, for example, during aging or disease (e.g. dementia). Hence, it is important to quantify the extent of these damages to better understand the physiological underpinning of normal and diseased brain.
The project aims to understand how the properties of vessels, e.g. stiffness, regulate the brain’s blood flow response. In particular, a computational model that predicts hemodynamic changes in the brain, which correspond to neuroimaging data, will be used to investigate how its physiological parameters affect the resulting neurovascular response. The project will involve modelling and data analysis. Hence, it would suit students with a background in physics, mathematics, computer science, or a related discipline, and an interest in neuroscience. Some experience in programming (e.g. in MATLAB) is also required.