This project will use a well-developed in vivo model to investigate the role of various drugs in the prevention of bowel cancer. Using an inducible BRAF mutant mouse, we have observed the sequential development of intestinal hyperplasia, polyps and ultimately advanced cancer, in a model that closely mimics human serrated neoplasia. This project will investigate therapeutic intervention to reduce the incidence of polyps and prevent cancer. Molecular studies using techniques such as mutation detection, DNA methylation, expression microarrays and immunohistochemistry will also be utilised to study the effects of the interventions.
This project would suit a highly motivated student with an interest in colorectal cancer genetics and therapy, who enjoys working individually and as part of a team.