It is now recognised that there are several different types of cells death. Importantly, the mode of cell death affects the ensuing immune response. We have recognised an important role for necroptosis in the induction of type-2 inflammation and immunity, which is the predominant module of immunity that underpins allergic diseases such as asthma. In this project we will employ experimental mouse models and in vitro culture models of primary airway epithelial cells to elucidate the molecular processes that initiate and regulate necroptosis.
Associate Professor Simon Phipps | email@example.com