Given the association between scabies and severe microbial disease, there is a need to understand how anti-scabies treatment impacts on pathogens associated with the mite. Our work showed that current scabies treatments may not restore healthy microbiota in porcine skin. This is important because broad-spectrum antibiotics are only used to treat advanced scabies, but early scabies lesions often show signs of bacterial infection. In collaboration with the Menzies School of Health Research in Darwin, we will study scabies lesions for their microbial content compared to contralateral uninfected sites during the course of treatment of patients involved in the moxidectin Phase II dose-finding study. This study, commencing in mid-2018, is a perfect opportunity to monitor the longitudinal impact of drug exposure on mite infestation and skin microbiota.
Dr Katja Fischer | email@example.com