Student Projects

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Chronic Disorders

Statistical Genetics Laboratory: Eye disease genetics

Suitable background: The post is ideally suited to someone with an undergraduate or Master’s degree in genetic epidemiology, epidemiology, statistics or bioinformatics. Experience in the analysis/manipulation of large datasets and a good knowledge of computing is desirable. Experience in ophthalmic genetics advantageous but not essential. Non-statistical applicants must be able to demonstrate some knowledge of […]

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Statistical Genetics Laboratory: Genetics of skin cancer

Suitable background: The post is ideally suited to someone with an undergraduate or Master’s degree in genetic epidemiology, epidemiology, statistics or bioinformatics. Experience in the analysis/manipulation of large datasets and a good knowledge of computing is desirable. Experience in cancer genetics and/or molecular biology advantageous but not essential. Non-statistical applicants must be able to demonstrate […]

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Respiratory Immunology Laboratory: Cell death pathways and the induction of type-2 inflammation

It is now recognised that there are several different types of cells death. Importantly, the mode of cell death affects the ensuing immune response. We have recognised an important role for necroptosis in the induction of type-2 inflammation and immunity, which is the predominant module of immunity that underpins allergic diseases such as asthma. In […]

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Respiratory Immunology Laboratory: Eicosanoids and viral exacerbations of chronic obstructive pulmonary disease (COPD)

Prostaglandin D2 is a lipid mediator generated from the metabolism of arachidonic acid. We recently discovered (Werder et al, Science Translational Medicine) that PGD2 can enhance or suppress the production of type III IFN, a potent antiviral cytokine. This contrasting effect is dependent on the receptor subtype that is activated. In both COPD and asthma, […]

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Respiratory Immunology Laboratory: Microbiome and immune cell development in early life

The microbiome is known to affect immune development. For example, germ-free mice have fewer Peyer’s patches in the gut wall, suggesting that the gut microbiome regulates the formation of this lymphoid tissue. Other studies have shown that germ-free mice have fewer natural killer T cells. Both the microbiome and the immune system develop postnatally (predominantly […]

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Respiratory Immunology Laboratory: Insights into the influence of maternal diet on the severity of infant viral bronchiolitis

Viral bronchiolitis is an infection of the small airways (bronchioles) characterised by the infiltration of neutrophils, oedema, and shedding on the epithelial cells that line the airway. A recent population study found that the offspring of mothers who ate a poor diet in the third trimester were predisposed to severe viral bronchiolitis. We have modelled […]

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Mucosal Immunology Group: Development of a novel therapeutic pipeline for the treatment of inflammatory diseases

This project is suitable for a Masters, Honours or PhD student We have discovered hookworm proteins and peptides able to modulate the immune response and protect against allergic and autoimmune diseases (like IBD and colitis). We are interested in developing these novel compounds into the clinics and determine how the proteins alter cellular function. Gut-resident […]

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Mucosal Immunology Group: Role of parasitic infection in early life on the development of allergic diseases

This project is suitable for a PhD student The Western lifestyle, characterised by a nutrient-poor diet, sedentary lifestyle, and exposure to antibiotics / pollution, and the Hygiene Hypothesis have been directly implicated in the development of allergic diseases. Parasites, such as hookworms, modulate the microbiome and provide important maturation signals to the immune system that […]

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Mucosal Immunology Group: Modulation of the microbiome to promote the maturation of the immune system in the perinatal period

This project is suitable for a PhD student Nearly one billion people globally suffer from allergies responsible for significant morbidity and reduced quality of life. Our group has discovered a process during the neonatal “Window of Opportunity” that prevents allergy from developing later in life. We propose to understand the mechanisms that allow neonates to […]

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