Student Projects

Modeling viral-associated diseases to improve adoptive T cell outcomes

Project Supervisor/s

This project would be highly suitable for a motivated PhD candidate. However, aspects of this project work could also be refined for a full-time Honours or Masters student project.

BACKGROUND

Epstein Barr Virus (EBV) infects around 95% of the global population and establishes lifelong persistence in patients through the latent infection of otherwise healthy B cells. While this persistent infection is asymptomatic in most people, EBV has been linked to a range of human cancers and in addition, has an aetiological role in the development of the autoimmune disease, Multiple Sclerosis.

In recent years we have developed a humanized animal model of EBV-driven disease that enables us to examine the infection, trafficking and therapeutic targeting of human EBV-infected B cells within a functional murine in vivo setting. Here, we are particularly interested in the ongoing development of laboratory techniques that expand our understanding of the interplay between ACT and the control of disease burden in vivo, including the development of new strategies to interrogate whether specific T cell signatures facilitate the preferential homing of ACT to distinct anatomical sites in the body.

The scope for this project is broad and will provide ample opportunity for the development of laboratory techniques including microscopy and/or live cell imaging, T cell sequencing and viral transduction.

To apply for this project, please contact the project supervisor/s

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