Astrosenescence: The role of senescence and cell cycle disruption in Space Travel.
Project aim To identify and validate the presence of cellular senescence and associated pathways in mice and human tissues exposed to spaceflight, using single-cell and bulk RNA sequencing data. Background Spaceflight presents unique stressors, including microgravity and cosmic radiation, which may accelerate cellular aging processes such as senescence. Cellular senescence is characterized by permanent cell […]
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EBV, where are you hiding?
This project is suitable for an Honours students. Background: Epstein Barr Virus (EBV) is a common human viral infection that is most well known as the cause of infectious mononucleosis/glandular fever. Following acute exposure, EBV establishes lifelong latent infection in B cell lymphocytes with periodic stages of reactivation that lead to viral shedding. While benign […]
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Investigating the neuroscience of lifestyle interventions for mental health
This project is suitable for a PhD student. Background Our everyday behaviours, such as physical activity, sleep, diet, meditation, and social connections, have a potent impact on our mental health and the health of our brain. There is growing research to harness this power by developing lifestyle-based interventions for mental health and investigating how they […]
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Sex-specific lethality and sterility for mosquito biocontrol
This project is suited to Honors, Masters and PhD students. BACKGROUND Dangerous arboviruses such as dengue, Zika and chikungunya, that infect hundreds of millions of people and kill hundreds of thousands around the globe each year, are primarily transmitted by females of the mosquito Aedes aegypti. Due to rapidly evolving mosquito resistance to commonly used […]
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Genomics of mosquito populations in space and time – finding optimal control solutions
This project is suited to Honors and Masters students. BACKGROUND Dengue and Zika fever are dangerous viral diseases transmitted by the mosquito Aedes aegypti. This mosquito is found around the global tropics, and different parts of the world face different control challenges. In Singapore, this mosquito is generally found in low numbers throughout a year, […]
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Genetics-based Approaches to Precision Medicine for Chronic or Noncommunicable Diseases
This project is suited to a PhD student with experience in genetic epidemiology, epidemiology, biostatistics or bioinformatics. Experience in the analysis and manipulation of large datasets and a good knowledge of computing is desirable. Experience in cancer genetics and clinical medicine are advantageous but not essential. Non-statistical applicants must be able to demonstrate some knowledge […]
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Targeting Novel Eph Receptors in Solid Tumours
This project is suitable for PhD students. BACKGROUND We have generated well-characterised monoclonal antibodies (mAbs) against several Eph and ephrin receptor proteins that are present on distinct cell populations in several solid tumours such as colon, breast, prostate and brain cancer. We plan to use these novel mAbs to effectively target these aggressive treatment refractory […]
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Machine learning analysis of imaging and sequencing data for cancer diagnosis and prognosis.
This project is suitable for students with experience in computational programming, with a good theoretical background in statistics and machine learning, and are familiar with sequencing data and imaging data. BACKGROUND Almost all suspected cancer patients undergo tissue biopsies stained and examined by pathologists using light microscopy. This method is highly variable, blind to cancer […]
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The genetics of dizygotic twinning in Africans, Asians and Europeans; relationship to female infertility.
This project is suitable for PhD students. BACKGROUND Dizygotic (DZ, nonidentical) twinning runs in families and various family and pedigree studies have shown it to have a genetic component around 20-30%. Recent GWAS of over 8000 mothers of DZ twins of European ancestry has found at least 6 genes influencing this trait, most with obvious […]
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