The genetic epidemiology group is at the forefront of work on the genetics of alcoholism and, from questionnaire and interview studies involving 6,000 twins over the past 19 years, we have estimated that in Australia 64 percent of variance in liability to alcoholism is genetic in both men and women. We are also interviewing offspring, aged 14-28, of twins, with a view to disentangling the complex relationship of conduct disorder and alcohol dependence. New NIH grants will enable us to search for major genes influencing risk of alcoholism and smoking addiction.
(N.G. Martin, D. Statham, in collaboration with A.C. Heath and P.A.F. Madden, Washington University School of Medicine, St Louis and W. Slutske, University of Missouri)