Typical migraine is a frequent, debilitating and painful disorder that normally affects people during their most productive years (up to 25 % of females and 7.5 % of males in Western populations). Additionally, several studies have demonstrated a cross-sectional relation between psychiatric disorders (namely anxiety and depression) and migraine in community samples. This project will collect a sample with sufficient power to perform a genome wide-linkage screen to i) identify novel susceptibility genes, and ii) confirm previously reported susceptibility genes for migraine and co-occurring psychiatric disorders. The susceptibility genes identified (and confirmed) in this sample will provide clues to the further elucidation of the complex molecular pathways of migraine (and co-occurring psychiatric disorders) and, finally, will help in the development of diagnostic tests and rational treatment strategies.
(D.R. Nyholt, B.J. Mowry, N.G. Martin)