Dr | Research Officer+61 7 3845 3070
Sebastien Jacquelin is a researcher with special interest in Stem cell, Cancer, Epigenetic, DNA topology and Tumour Immunology. He received his PHD from the University of Paris Sud XI in 2013 in cancer immunology and Life Science in 2013. He performed a post doc in the field of leukaemia in QIMR Berghofer in Brisbane and acquired expertise in geno-editing epigenetic and cancer biology. In 2019, he joined the Functional Cancer Genomics laboratory. His work aim to understand how genetic variants alter non-coding genome dynamic, chromatin topology and contributes to breast cancer development.
2019–current: Research Officer-Functional Cancer Genomics Laboratory
2014-2019: Gordon and Jessie Gilmour Leukaemia Laboratory QIMR Berghofer Brisbane Australia
2010-2013: PhD, INSERM, Pitié-Salpêtrière hospital Paris, France
2009-2010: Research engineer, INSERM, St Antoine hospital Paris, France
2006-2009: Research engineer, INSERM, Necker hospital Paris, France
2003-2006: Sales engineer, ADS Laminaire, Le Pre St Gervais, France
2003: Research assistant INSERM, Bichat hospital
2002: Research assistant, CEA, (Atomic Energy Commissariat), Cadarache, France
2001-2002: Research assistant, Pasteur Institute, Paris, France
2000-2001: Research assistant, CEA, St Louis hospital Paris, France
1997-1999: Research assistant, IRSN (Radioprotection and nuclear Safety Institute), FAR, France
The Functional Cancer Genomics Laboratory focuses on understanding how DNA variation contributes to cancer risk and development. The laboratory is particularly interested in translating the findings from cancer genome-wide association studies (GWAS). Our research aims to understand how DNA sequence variation effects local topology and causes changes in gene expression that promotes cancer transformation. Using RNA CaptureSeq we identified >4000 Long noncoding RNAs (LncRNAs) transcribed from cancer risk regions that were not previously annotated. The expression of LncRNAS is cell type specific and define biological signature allowing precise identification of cell subtype. Importantly, LncRNAs expression pattern discriminate normal cells from cancer cells. My research aim to understand the role of these newly identified LncRNAs in normal and cancer cell development. To perform my research I have developed a CRISPR Cas13d screening platform to target the non-coding genome and assess its function in primary cells and cancer cells development.
Sebastien Jacquelin’s research career have been mainly devoted to the field of cancer, immunology and epigenetic with specific focus in leukaemia and Breast cancer.