Our People

Michelle Hill

Associate Professor | Principal Research Fellow | Group Leader

Precision & Systems Biomedicine

+61 7 3845 3020



Associate Professor Michelle Hill obtained her PhD at the University of Queensland on insulin signalling using phosphoproteomics. Her postdoctoral work in Switzerland, Ireland and at the Institute for Molecular Bioscience, University of Queensland focussed on various aspects of signalling using subcellular proteomics. With a passion for translational proteomics research, she established the Cancer Proteomics Group at the University of Queensland Diamantina Institute in 2009. After successfully developing clinical proteomics research, and establishing a proteomics amyloid typing test for the Princess Alexandra Hospital in Brisbane, Associate Professor Hill moved her laboratory to QIMR Berghofer in 2017 to broaden her research program in the Precision and Systems BioMedicine Laboratory to include lipidomics, metabolomics and chronic and mental health conditions.

Associate Professor Hill has been an active member of the Australasian Proteomics Society since 2007, being the Queensland representative on the board for many years. She initiated the Queensland Mass Spectrometry Symposium to encourage local networking. Associate Professor Hill has been an elected member of the international Human Proteome Organisation (HUPO) Council since 2016 and served as the Secretary General for 2019 and 2020.


2020-current: Honorary Associate Professor, University of Queensland Centre for Clinical Research, Faculty of Medicine, University of Queensland

2017-current: Head, Precision & Systems Biomedicine Laboratory, QIMR Berghofer


2009-2017: Head, Cancer Proteomics Group, University of Queensland Diamantina Institute, University of Queensland

2014-2016: Academic Lead, Translational Research Institute Proteomics & Mass Spectrometry Core Facility

2004-2008: Research Officer, Institute for Molecular Bioscience, University of Queensland

2002-2003: Post-doctoral Research Fellow, Trinity College Dublin, Dublin, Ireland

2000-2002: Post-doctoral Research Fellow, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland






Associate Professor Hill’s translational research aims to improve health outcomes by (1) developing better diagnostics, and (2) understanding metabolic disturbances particularly of membrane lipids (fats) that lead to diseases. Her research program focuses on early disease detection and non-drug prevention approaches, to empower the public with knowledge and tools to actively maintain wellness. Associate Professor Hill works with a multi-disciplinary team and interdisciplinary collaborators to achieve these goals.

For the past decade, Associate Professor Hill’s research has addressed unmet clinical needs in cancer including:

  • early detection of cancers that have very poor prognosis due to late detection – oesophageal adenocarcinoma, ovarian cancer, pancreatic cancer
  • role of cholesterol in prostate cancer metastasis, and development of a test for prostate cancer monitoring
  • understanding how obesity increases cancer risk, particularly the role of lipids (fats)
  • understanding how exercise and dietary components contribute to health at a cellular and physiological level
  • addressing urgent needs for rapid infectious diseases screening and diagnostics using rapid infrared technology

Her research combines cell biology and biochemistry knowledge with cutting edge multi-omics technologies in the “wet-lab” with sophisticated computational algorithms (“dry-lab”).


  • implementation of amyloid typing proteomics test at Princess Alexandra Hospital Amyloidosis Centre (Translational Research Institute Proteomics Core)
  • discovery and patenting of blood glycoproteins for early detection of oesophageal cancer (adenocarcinoma), which can be used for Barrett’s oesophagus patient surveillance
  • develop the only lipid raft proteomics database, RaftProt
  • identified hnRNPK protein secreted by exosomes as marker for prostate (and colorectal) cancer metastasis, and the reduction of its release through cholesterol lowering or use of omega-3 polyunsaturated fatty acids
  • proof-of-concept work on use of ATR-FTIR (infrared) spectroscopy for in infectious diseases, including microbial antibiotic resistance screening, COVID-19 severity prediction from blood samples


2019-current: International Society for Extracellular Vesicles

2012-current: American Society for Biochemistry and Molecular Biology

2010-current: Australian Society for Medical Research

2007-current: Human Proteome Organization

2007-current: Australasian Proteomics Society

2006-current: Australian Society for Biochemistry and Molecular Biology



  • Australian Academy of Health and Medical Sciences Mentorship Travel Award


  • Australian Research Council Future Fellowship


  • Runner-Up Senior Category, Australian Society for Medical Research Qld Health and Medical Research Award
  • Finalist, UniQuest Trailblazer Competition


  • Princess Alexandra Hospital Research Week Basic Research Poster Prize


  • NHMRC Career Development Award


  • National Association of Research Fellows of NHMRC Postdoctoral Investigator Award, awarded to a single Australian post-doctoral researcher each year based on research output


  • Deans Award for outstanding PhD thesis


2000: PhD, University of Queensland

1995: B.Sc. Hons (First class), University of Queensland

1994: Parallel B.Sc., B.A., University of Queensland