Our People

Michelle Hill

Associate Professor | Group Leader

Precision & Systems Biomedicine

+61 7 3845 3020

michelle.hill@qimrberghofer.edu.au

 

CAREER HISTORY

Associate Professor Michelle Hill obtained her PhD at the University of Queensland on insulin signalling using phosphoproteomics. Her postdoctoral work in Switzerland, Ireland and at the Institute for Molecular Bioscience, University of Queensland focussed on various aspects of signalling using subcellular proteomics. With a passion for translational proteomics research, she established the Cancer Proteomics Group at the University of Queensland Diamantina Institute in 2009. After successfully developing clinical proteomics research, and establishing a proteomics amyloid typing test for the Princess Alexandra Hospital in Brisbane, Associate Professor Hill moved her laboratory to QIMR Berghofer in 2017 to broaden her research program in the Precision and Systems BioMedicine Laboratory to include lipidomics, metabolomics and chronic and mental health conditions.

Associate Professor Hill has been an active member of the Australasian Proteomics Society since 2007, being the Queensland representative on the board for many years. She initiated the Queensland Mass Spectrometry Symposium to encourage local networking. Associate Professor Hill has been an elected member of the international Human Proteome Organisation (HUPO) Council since 2016 and served as the Secretary General for 2019 and 2020.

 

CURRENT APPOINTMENTS

2020-current: Honorary Associate Professor, University of Queensland Centre for Clinical Research, Faculty of Medicine, University of Queensland

2017-current: Head, Precision & Systems Biomedicine Laboratory, QIMR Berghofer

 

PREVIOUS APPOINTMENTS

2009-2017: Head, Cancer Proteomics Group, University of Queensland Diamantina Institute, University of Queensland

2014-2016: Academic Lead, Translational Research Institute Proteomics & Mass Spectrometry Core Facility

2004-2008: Research Officer, Institute for Molecular Bioscience, University of Queensland

2002-2003: Post-doctoral Research Fellow, Trinity College Dublin, Dublin, Ireland

2000-2002: Post-doctoral Research Fellow, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

 

ORCID NUMBER

https://orcid.org/0000-0003-1134-0951

 

RESEARCHER ID

G-4417-2010

 

CURRENT AREA OF RESEARCH

Associate Professor Hill’s translational research aims to improve modifiable health outcomes by (1) developing better diagnostics, and (2) integrative study of cell membrane disturbance that lead to diseases. Rather than potentially toxic and expensive therapies, her program focuses on early disease detection and non-drug prevention approaches, to empower the public with knowledge and tools to actively maintain wellness. Associate Professor Hill works with a multi-disciplinary team and interdisciplinary collaborators to achieve these goals.

For the past decade, Associate Professor Hill’s research has addressed unmet clinical needs in cancer including:

  • early detection of cancers that have very poor prognosis due to late detection – oesophageal adenocarcinoma, ovarian cancer, pancreatic cancer
  • role of cholesterol in prostate cancer metastasis, and development of a test for prostate cancer monitoring
  • understanding how obesity increases cancer risk, particularly the role of lipids (fats)
  • understanding how exercise and dietary components contribute to health at a cellular and physiological level

Her research combines cell biology and biochemistry knowledge with cutting edge multi-omics technologies in the “wet-lab” with sophisticated computational algorithms (“dry-lab”).

 

RESEARCH HIGHLIGHTS

  • implementation of amyloid typing proteomics test at Princess Alexandra Hospital Amyloidosis Centre (Translational Research Institute Proteomics Core)
  • discovery and patenting of blood glycoproteins for early detection of oesophageal cancer
  • (adenocarcinoma), which can be used for Barrett’s oesophagus patient surveillance
  • develop the only lipid raft proteomics database, RaftProt
  • discovery and demonstrated the role of CAVIN1/PTRF protein in caveolin-1 and caveolae function
  • established novel targeted mass spectrometry assays for cytokines and for tubulin acetylation

 

PROFESSIONAL MEMBERSHIPS

2019-current: International Society for Extracellular Vesicles

2012-current: American Society for Biochemistry and Molecular Biology

2010-current: Australian Society for Medical Research

2007-current: Human Proteome Organization

2007-current: Australasian Proteomics Society

2006-current: Australian Society for Biochemistry and Molecular Biology

 

AWARDS RECOGNITION

2017:

  • Australian Academy of Health and Medical Sciences Mentorship Travel Award

2012:

  • Australian Research Council Future Fellowship

2010:

  • Runner-Up Senior Category, Australian Society for Medical Research Qld Health and Medical Research Award
  • Finalist, UniQuest Trailblazer Competition

2009:

  • Princess Alexandra Hospital Research Week Basic Research Poster Prize

2009:

  • NHMRC Career Development Award

2004:

  • National Association of Research Fellows of NHMRC Postdoctoral Investigator Award, awarded to a single Australian post-doctoral researcher each year based on research output

2001:

  • Deans Award for outstanding PhD thesis

 

EDUCATIONAL BACKGROUND

2000: PhD, University of Queensland

1995: B.Sc. Hons (First class), University of Queensland

1994: Parallel B.Sc., B.A., University of Queensland