Associate Professor Michelle Hill obtained her PhD at the University of Queensland (UQ) on insulin signalling using phosphoproteomics. Her postdoctoral work in Switzerland, Ireland, and at Institute for Molecular Bioscience UQ focussed on various aspects of signalling using subcellular proteomics. With a passion for translational proteomics research, she established the Cancer Proteomics Group at the UQ Diamantina Institute in 2009. Through interdisciplinary collaborations, the group has successfully developed a laboratory test for amyloidosis subtyping, and is in the process of developing a blood test for oesophageal adenocarcinoma detection. Michelle is an elected member of the international Human Proteome Organisation (HUPO) Council, and inaugural chair of the Queensland Mass Spectrometry Symposium. In April 2017, Michelle’s research group will begin a new chapter at the QIMR Berghofer Medical Research Institute, where she intends to expand her fledgling lipidomics and chemical analysis capabilities.
Current QIMR Berghofer appointment
- 2017 – current: Head, Precision & Systems Biomedicine Laboratory
- 2017 – current: Principal Research Fellow, UQ Diamantina Institute, The University of Queensland, Australia
- 2009 – 2017: Head, Cancer Proteomics Group, UQ Diamantina Institute, The University of Queensland, Australia
- 2014 – 2016: Academic Lead, Translational Research Institute Proteomics & Mass Spectrometry Core Facility
- 2004 – 2008: Research Officer, Institute for Molecular Bioscience, UQ, Australia
- 2002 – 2003: Post-doctoral Research Fellow, Trinity College Dublin, Dublin, Ireland
- 2000 – 2002: Post-doctoral Research Fellow, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Current Area of Research
Multidisciplinary program in translational research with the following current themes:
Multi-disciplinary collaborations including clinical, biostatistics and nanotechnology have been established to facilitate new marker discovery, validation and translation. Molecular target discovery techniques include our novel lectin-magnetic bead array (LeMBA) for glycosylation changes on glycoproteins, and extracellular vesicle (exosomes and microvesicles) as biomarkers. An exemplar of translational implementation is our work with the Princess Alexandra Hospital Amyloidosis Centre to provide accurate amyloidosis subtyping using mass spectrometry.
Systems Biomedicine – interplay between fats, bugs and proteins
Integrated investigation into complex systems such as the human body in health and disease, through systematic analysis of proteins and lipids in various subcellular organelles. Initial focus has been on cholesterol-rich membranes, also term lipid raft domains. A new research program investigates the role of microbes/microbiota on cancer development and progression. This multi-disciplinary program involves meta-genomics, meta-proteomics as well as microbial culture, peptide and metabolite analysis and cellular function assays.
Proteomics and lipidomics method development
To facilitate clinical and high throughput research, my group has established several semi-automated pipelines using a liquid handler, as well as new analytical methods.
Associate Professor Michelle Hill has 20+ years experience in biochemistry and proteomics research. She was recently recruited to the QIMR Berghofer Medical Research Institute, following 8 years leading the Cancer Proteomics Group at The University of Queensland Diamantina Institute. Her research program has been supported by the ARC and NHMRC. In addition to highly cited, paradigm-shifting basic research, her translational research program has had significant impact on the diagnosis of amyloid subtypes. The Princess Alexandra Hospital Amyloidosis Centre receives referrals from Australasia for proteomics subtyping. Her serum biomarker research program has led to an international patent, with ongoing discovery and validation to support commercial development. Her international standing in the area of proteomics is recognised by her election on to the international Human Proteome Organisation (HUPO) Council in 2015. At QIMR Berghofer Medical Research Institute, she will have access to more cutting edge mass spectrometers, broader multi-disciplinary collaboration to support and expand the diagnostics development program.
- 2017: Australian Academy of Health and Medical Sciences Mentorship Travel Award
- 2012: ARC Future Fellowship (deferred start 1/1/2013)
- 2010: Runner-Up Senior Category, Australian Society for Medical Research Qld Health and Medical Research Award
- 2010: Finalist, UniQuest Trailblazer Competition
- 2009: Princess Alexandra Hospital Research Week Basic Research Poster Prize, given to the best poster communicating a basic research project
- 2009: NHMRC Career Development Award
- 2004: National Association of Research Fellows of NHMRC Postdoctoral Investigator Award, awarded to a single Australian post-doctoral researcher each year based on research output
- 2001: Deans Award for outstanding PhD thesis
- 2000: PhD, University of Queensland, Australia
- 1995: B.Sc. Hons (First class), University of Queensland, Australia
- 1994: Parallel B.Sc., B.A., University of Queensland, Australia