Current Area of Research
Immune CD4+ T cells are important to protect against malaria, a parasitic infection that continues to inflict millions globally. CD4+ T cells differentiate into effector cells and then into memory cells that retain memories of previous infections, thus allowing repeated infections to be dealt with more easily. However, this “memory” generation or maintenance is poor during malaria. Using cutting-edge technology, such as T-cell receptor transgenic mice and single-cell genomics, my project tests the hypothesis that CD4+ T effector cells could directly convert into memory cells during malaria, and further describes the underlying transcriptomic processes to improve immunological memory to malaria.