Associate Professor Jason Mulvenna
Team Head/NHMRC CDF
Phone: +61 7 3845 3868
Current QIMR appointment
My current work is aimed towards using high-throughput molecular techniques, including proteomics, next generation sequencing, structural biology, bioinformatics and machine learning, to build a picture of system-wide biological activity and how this changes in the face of challenges from parasites, disease and cancer. This not only provides insight into the biology underlying disease but provides protein and peptide targets for drug and vaccine development, multi-molecule expression ‘signatures’ for the diagnosis and prognosis of disease and potential novel therapeutics in the form of peptides or small molecules.
Other current appointments
- Associate Professor, School of Biomedical Science, The University of Queensland.
- Senior Research Fellow, College of Tropical Health and Medicine, James Cook University.
- 2010-2012: Senior Lecturer, James Cook University.
- 2006-2010: Research Officer, QIMR.
- 2005-2006: Research Fellow, Harvard Medical School.
Current Area of Research
- Proteomics and structural biology.
- Nasopharyngeal carcinoma.
- Jellyfish toxicology.
- Rational drug design.
- NHMRC 1108064 – The bioactivity and binding partners of Irukandji and Box Jellyfish venom.
- NHMRC 1051627 – Biomarkers for the progression of cholangiocarcinoma.
- NIH RO1 PA08156 – Biomarkers of Opisthorchis viverrini-induced cholangiocarcinoma.
- NIH RO1 1R01CA164719-01A1 – Role of liver fluke granulin in cholangiocarcinogenesis.
- Scabies, QIMR Berghofer.
- Molecular Parasitology, QIMR Berghofer.
- Human Immunity Group, QIMR Berghofer.
- George Washington University, Department of Microbiology, Immunology, and Tropical Medicine, Washington DC, USA.
- National Cancer Institute, Infections and Immunoepidemiology, Washington DC, USA.
- Khon Kaen University, Department of Pathology and Department of Parasitology, Khon Kaen, Thailand.
- Australian Institute of Marine Science, Townsville, Australia.
- James Cook University, Centre for Biodiscovery and Molecular Development of Therapeutics and Centre for Biosecurity in Tropical Infectious Diseases, Cairns, Australia.
- The University of Queensland, School of Biomedical Science, Brisbane, Australia.
- I published some of the first high-throughput proteomic analyses of helminth parasites resulting in the identification of parasitic mitogens, immuno-regulatory proteins and other proteins important during parasitic infection.
- I established a biomarker program using next-generation sequencing and SWATH proteomics to identify protein and miRNA biomarkers of cancer. This work provided the first comparisons of tumour and circulating miRNA in cancer patients and has been extended to other infection-related cancers, including nasopharyngeal carcinoma, leading to a better understanding of how tumour miRNAs interact with surrounding tissue and affect the circulating miRNA profile.
- I published the first characterisation of venom from the box jellyfish Chironex fleckeri and this work has led to a better understanding of how the most venomous organism on the planet is able to elicit the sometimes fatal symptoms of jellyfish envenomation.
- 2013-current: Guest Editor for PLoS Neglected Tropical Disease.
- 2013-current: Editorial Board of International Journal of Parasitology.
- 2012-current: Academic Editor of PLoS One.
- 2009-current: American Society of Tropical Medicine and Hygiene.
- 2007-current: Australian Society for Parasitology.
- 2003-current: Australian and New Zealand Society for Magnetic Resonance.
- 2008-2013: Australian Society for Parasitology, Council Member.
- 2011-2014: NHMRC Career Development Fellowship.
- 2007-2010: NHMRC Peter Doherty Training Fellowship.
- 2005: Deans Commendation for Outstanding Research Higher Degree Thesis.
- 2001-2004: Australian Postgraduate Award.
- 2001-2004: IMB Top-up Scholarship.
- 2000: Alumni Prize for Highest Overall Mark in Biochemistry Honours.
- 1996, 1998, 1999: Deans Commendations for High Achievement.
- PhD, Nuclear Magnetic Spectroscopy, The University of Queensland.
- Biochemistry Honours, First Class, The University of Queensland.
- Bachelor of Science, The University of Queensland.
- Bachelor of Commerce, The University of Queensland.