Current QIMR Berghofer appointment
- 2016 – current: Team Head, Neurogenomics
- 2014 – 2015: Group Leader, Garvan Institute of Medical Research, Sydney, NSW.
- 2012 – 2014: Senior Research Officer, Garvan Institute of Medical Research, Sydney, NSW.
- 2011 – 2012: Research fellow, The Institute for Molecular Bioscience, The University of Queensland.
- 2007 – 2011: Post-doctoral researcher, The Queensland Brain Institute, The University of Queensland.
- 2006: Research Assistant, The Queensland Brain Institute, The University of Queensland.
- 1993 – 2001: Research Assistant, Neurocrine Biosciences Inc.
Current Area of Research
Dr Guy Barry‘s group investigates and validates genome-wide transcriptomic data to provide insight into how the human brain functions. For this it employs cutting-edge technologies such as:
- induced pluripotent stem cells (iPSCs)
- next generation sequencing (NGS)
- advanced bioinformatic analyses
- adaptive evolution and real-time heritability.
Understanding how the human brain works has historically been restricted due to the lack of a suitable human model and the ability to interrogate the entire transcribed human genome. Recent innovations in iPSC technology has permitted an unprecedented view into the biology of human cellular function as many cell types, including brain cells, can be derived from these ‘stem’ cells.
Furthermore, the emergence of powerful bioinformatic capabilities has extraordinarily advanced the field of genomics and transcriptomics over the last decade. The laboratory is exploring using a combination of iPSC and NGS technologies; particularly how mRNAs, long non-coding RNAs and small RNAs combine to underpin human cognitive advancement and psychiatric disease.
What makes us human? How has newly evolved regulatory sophistication occurred? How can we understand and treat psychiatric disease? These answers are important and exciting questions in human biology using the brain as a model, and the laboratory seeks to answer them.
Students are current being accepted should they wish to be part of the dynamic group.
- Uncovered the first mechanistic link between long non-coding RNAs and schizophrenia (Barry et. al., Molecular Psychiatry, 2014).
- Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB).
- Australian Society for Medical Research.
- Australian Neuroscience Society.
- InnoCentive Challenge award: 20 April 2015 ($5,000) InnoCentive 9933446 – ‘Novel Treatment Approaches to Cure Inflammatory Bowel Diseases’. This stems from work undertaken during my PhD studies investigating Crohn’s disease.
- Young Garvan Award (Finalist) 2014: Awarded $10,000 for research.
- The Society for Neuroscience Chapters Postdoctoral Trainee Travel Award 2008, Neuroscience 2008, November, Washington, DC.
- The Bill Evans Memorial Young Investigator Award, The Australian and New Zealand Society for Neuropathology, 28th Annual Scientific Meeting, 24 May 2008, Royal Brisbane Hospital, Brisbane.
- 2002 – 2006: Doctor of Philosophy, The University of Queensland.
- 1988 – 1991: Bachelor of Science, Microbiology, The University of Cape Town, South Africa.