Professor Georgia Chenevix-Trench is a Senior Principal Research Fellow of the NHMRC, a Fellow of the Australian Academy of Sciences and of the Australian Academy of Health and Medical Sciences, and Head of the Cancer Genetics Laboratory and the Department of Genetics and Computational Biology at the QIMR Berghofer in Brisbane. She is the author of more than 400 peer-reviewed papers, and has been instrumental in the collection of public resources such as kConFab, the Australian consortium for research into familial breast cancer. She is the leader of the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), and a founding member of the Breast and Ovarian Cancer Association Consortia, which have identified almost 200 novel breast and ovarian cancer susceptibility loci since the advent of genome-wide association studies. A major focus of her current research is to work out the function of the alleles associated with cancer risk, and to identify their target genes.
Current QIMR Berghofer appointment
- Senior Scientist, Cancer Genetics
Other current appointments
- Conjoint Professor, Department of Medicine, The University of Queensland
- 2007 – 2011: NHMRC Senior Principal Research Fellow, QIMR
- 2004 – 2006: NHMRC Principal Research Fellow, QIMR
- 1999 – 2003: NHMRC Senior Research Fellow, QIMR
- 1996 – 1998: NHMRC Research Fellow, QIMR
- 1992 – 1995: NHMRC R. Douglas Wright Fellow, QIMR
- 1989 – 1991: Research Officer in the Joint QIMR – The University of Queensland Oncology Programme
- 1986 – 1989: Research Officer, QIMR
- 1986: Post-doctoral fellow in the Department of Human Genetics, Medical College of Virginia, USA
Current Area of Research
- Cancer Genetics
- Understanding germline variation underlying individual differences in risk of breast and ovarian cancer.
- Genes involved in response to chemotherapy in patients with ovarian cancer.
- Evaluation of the role of the telomerase gene, TERT, in susceptibility to breast and ovarian cancer.
- National Health and Medical Research Council of Australia Program and Project Grants
- Department of Defense, USA
- D and J Wilson Foundation
Selected publications from 2015
- Michailidou K, Beesley J, …Chenevix-Trench G, Hall P, Easton DF. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer Nature Genetics 47(4):373-80 (2015) PMID: 25751625.
- Kuchenbaeker K. ….. AntoniouAC, Chenevix-Trench G; Consortium of Investigators of Modifiers of BRCA1 and BRCA2. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature Genetics 47(2):164-71 (2015) PMID:25581431.
- Easton DF, Pharoah PD, Antoniou AC, Tischkowitz M, Tavtigian SV, Nathanson KL, Devilee P, Meindl A, Couch FJ, Southey M, Goldgar DE, Evans DG, Chenevix-Trench G, Rahman N, Robson M, Domchek SM, Foulkes WD. Gene-panel sequencing for predicting breast cancer risk: a note of caution. New England Journal of Medicine 372(23):2243-57 (2015) PMID:26014596
- Guo et al Identification of novel genetic markers of breast cancer survival. Journal of the National Cancer Institute Apr 18;107(5) (2015) PMID:25890600.
- Darabi, H., McKue K. …. Chenevix-Trench G. Polymorphisms in a putative enhancer at the 10q21.2 breast cancer risk locus regulate NRBF2 American Journal of Human Genetics pii: S0002-9297(15)00187-1 (2015) PMID:26073781.
- Kar, S., Beesley, J. …. Chenevix-TrenchG, Eeles R, Pharoah PD, Lambrechts D. Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discovery. 6:1052-67 (2016) PMID 27432226.
- Dunning, S. … Chenevix-Trench G, Antoniou AC, Easton DF,Edwards Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nature Genetics 2016 Feb 29. doi: 10.1038/ng.3521. [Epub ahead of print] PMID: 26928228.
- French, J, … Chenevix-Trench*G, deFazio* A, Edwards* SL, MacGregor* S, on behalf of OCAC. Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. Oncotarget 2016 Jan 31. doi: 10.18632/oncotarget.7047. [Epub ahead of print] PMID:26840454.
- Couch, F. … Chenevix-TrenchG, Pharoah PD, Monteiro AA, García-Closas M, Easton DF, Antoniou AC. Identification of four novel susceptibility loci for estrogen receptor negative breast cancer. Nature Communications 98(5):830-42 (2016) PMID 27117709.
- Li, J …. Chenevix-Trench, G. Point mutations in exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant American Journal of Human Genetics 2016 Apr 13. pii: S0002-9297(16)30036-2. doi: 10.1016/j.ajhg.2016.03.001. [Epub ahead of print] PMID: 27087319.
- Lawrensen, K. …. Chenevix-Trench G, Antoniou AC, Gayther SAFunctional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p13.1 Breast-Ovarian Cancer Susceptibility Locus. Nature Communications 2016 Sep 7;7:12675. doi: 10.1038/ncomms12675. PMID: 27601076.
- Amos, C. … Chenevix-TrenchG, Chanock SJ, Simard J, Easton DF The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancer. Cancer Epidemiol Biomarkers Prev. 2016 Oct 3. pii: cebp.0106.2016. PMID: 27697780.
- Phelan, C. … Chenevix-Trench*G, Goode* EL, Sellers* TA, Gayther* SA, Antoniou* AC, Pharoah* PD. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nature Genetics 2017 Mar 27. doi: 10.1038/ng.3826. [Epub ahead of print].
- Michailidou et al Large-scale genetic association analysis identifies more than 70 new breast cancer susceptibility loci and provides insights into underlying genomic features. Nature (in principle acceptance).
- Identification of the gene that causes GAPPS (gastric adenocarcinoma and proximal polyposis of the stomach).
- Identification of almost 200 risk loci for breast and ovarian cancer.
- Elucidation of target genes at the 19p13.1 and 10q21.2 2 risk loci.
- American Society of Human Genetics
- Human Genetics Society of Australasia
- American Association for Cancer Research
- National Association of Research Fellows
- Australasian Biospecimen Network Inc
- Australia and New Zealand Gynaecological Oncology Group
- 2015: Fellow of the Australian Academy of Health and Medical Sciences
- 2014: National Breast Cancer Foundation Patron’s Award for Innovation and Vision in Research
- 2014: NHMRC High Achiever in Australian Health and Medical Research
- 2014: Fellow of the Australian Academy of Science
- 2007: Ralph Doherty QIMR Prize for Outstanding Achievement and Leadership in Medical Research
- 2006: Sutherland Lecture (Human Genetics Society of Australasia), at the International Congress of Human Genetics, Brisbane
- 1985: PhD Medical College of Virginia, Richmond, USA
- 1980: BSc (Hons) Trinity College Dublin, Ireland