Associate Professor John Miles
Phone: +61 7 3845 3804
Associate Professor John Miles is Head of the Human Immunity Laboratory at the QIMR Berghofer Medical Research Institute. His research is focused on understanding human T cell biology and augmenting T cell function using transient modulation and engineering strategies.
Dr Miles has specialist expertise researching immune interactions and deconstructing the pathomechanisms of diseases in humans. In this field Dr Miles has published 76 articles which include nine invited reviews. Original research articles include papers in:
- Nature Immunology
- Cancer Discovery
- Annual Review of Immunology
- The Journal of Experimental Medicine
- Nature Communications
- The Proceedings of the National Academy of Sciences
- PLoS Pathogens
- The Journal of Immunology
- The Journal of Biological Chemistry
- Immunology & Cell Biology
- The European Journal of Immunology
- The Journal of Virology.
Dr Miles’ research into human immune system function has been recognised through 17 awards and prizes including the Centenary Medal from Her Majesty Queen Elizabeth II for Distinguished Service to Medical Research and the Community and the 2013 Young Tall Poppy Science Award from the Federal Government and Australian Institute of Policy and Science.
T cells are a group of white blood cells that belong to the immune system. The role of these sentinel cells is to protect the host through the identification and elimination of infectious agents and cancer. Through accidental recognition of self or innocuous targets, T cells can also damage the host by initiating and driving autoimmune disease, allergic reaction and organ rejection. In addition to core immunity, T cells can regulate the nervous system and even control the function of whole organs. Thus, understanding and controlling this powerful immune lineage has the potential to unlock new treatments across hundreds of human diseases.