Dr David Frazer obtained his Bachelor of Applied Science (Honours) from the Queensland University of Technology in 1997 and his PhD on iron homeostasis from QIMR Berghofer Medical Research Institute in 2003. He has since continued working on the role of iron in health and disease in the Iron Metabolism Laboratory at QIMR Berghofer.
His current research interests include:
- studying the regulation of the iron regulatory hormone hepcidin and investigating how this peptide can be manipulated to influence conditions such as hereditary haemochromatosis, the anaemia of inflammation and beta-thalassaemia
- investigating iron absorption and its regulation in pregnant and neonatal mammals
- examining the intestinal absorption of novel nanoparticulate iron supplements and exploring the role of intestinal iron content in conditions such as inflammatory bowel disease and intestinal tumourigenesis
- studying the role of iron in the development of age-related chronic disease
- investigating the role of iron in the pathogenesis of cystic fibrosis.
Research laboratories and groups
Iron Metabolism Laboratory
Professor Greg Anderson
Current Area of Research
- Iron homeostasis in health and disease
- Regulation of the peptide hormone hepcidin
- Pathogenesis of hereditary haemochromatosis and b-thalassaemia
- Iron supplementation
- Neonatal iron metabolism
- First to link hepcidin expression to iron loading in patients with hereditary haemochromatosis.
- Demonstrated a link between hepcidin expression and intestinal iron absorption.
- Showed that iron absorption during suckling is refractory to the inhibitory effects of circulating hepcidin.
- Demonstrated that stimulated erythropoiesis inhibits hepcidin production by interfering with the BMP6/SMAD signalling pathway in b-thalassamia.
- Showed that a novel nanoparticulate iron supplement is absorbed via the iron export protein ferroportin.
- Iron absorption and homeostasis during suckling.
- Mechanism of absorption and safety profile of a novel nanoparticulate iron supplement.
- The regulation of hepcidin in health and disease.
- The effect of iron on cystic fibrosis disease progression.
- CIB on NHMRC Project Grant (2014-2016) – Mechanisms of intestinal and systemic iron homeostasis in early infancy
- CIG on NHMRC Project Grant (2015-2017) – Abnormal lung iron homeostasis in cystic fibrosis
- Christopher Vulpe, University of Florida: The regulation of iron homeostasis, 14 publications.
- Jonathan Powell, MRC Human Nutrition Research, University of Cambridge: Use of nanoparticles to provide a more effective iron supplement, 3 publications.
- Dora Pereira, MRC Human Nutrition Research, University of Cambridge: Use of nanoparticles to provide a more effective iron supplement, 3 publications.
- Graham Radford-Smith, QIMR Berghofer Medical Research Institute: The use of iron supplements in patients with inflammatory bowel disease.
- David Reid, The Queensland Institute of Medical Research and the Prince Charles Hospital: Iron metabolism in cystic fibrosis.
- Australian Society for Biochemistry and Molecular Biology
- Australian Society for Medical Research
- Gastroenterological Society of Australia
- International BioIron Society
- American Association for the Advancement of Science
- The Australian Liver Foundation-Hospitality Industry Career Development Research Fellowship (2012)
- The Gastroenterological Society of Australia Bushell Postdoctoral Fellowship (2005)
- Gastroenterological Society of Australia, Queensland Branch 2000 Young Investigator Award (2000)
- Mackerras Scholarship – supplementary scholarship awarded by QIMR for outstanding students (1998)
- Royal Children’s Hospital Foundation Postgraduate Scholarship for PhD (1998)
- Queensland University of Technology University Medal for Academic Excellence (1997)
- BAppSc, PhD