Daniel Rawle
Dr | Research Officer
+61 7 3845 3733Daniel.Rawle@qimrberghofer.edu.au
Twitter @daniel_rawle
CAREER HISTORY
Dr Daniel Rawle completed his Bachelor of Science with first class honours in West Nile virus molecular virology at University of Queensland (UQ) in 2014. He did his PhD at QIMR Berghofer Medical Research Institute from 2015-2019 on virus-host interactions in HIV infection, characterising these interactions in molecular detail and exploiting them as drug targets. After obtaining his PhD he did a joint post-doc between QIMR and Queensland University of Technology (QUT) working on Zika virus-host interactions in a model of prostate infection. In 2019 he started a post-doc in the Inflammation Biology lab at QIMR investigating viral immunopathogenesis and virus-host interactions in Chikungunya, SARS-CoV-2, Zika, Ross River and Getah virus infection.
CURRENT APPOINTMENTS
2019-current: Research Officer, Inflammation Biology lab, QIMR Berghofer
PREVIOUS APPOINTMENTS
2019: Postdoctoral Research Fellow, Arbovirus Transmission and Evolution group, Queensland University of Technology
2019: Research Officer, HIV and Molecular Virology lab, QIMR Berghofer
2018-2019: Research Assistant, HIV and Molecular Virology lab, QIMR Berghofer
ORCID NUMBER
RESEARCHER ID
AAZ-4221-2020
CURRENT AREA OF RESEARCH
Dr. Rawle’s current area of research can be summarised as investigating virus-host interactions and responses in virus replication and immunopathology. In addition to being involved in a wide range of collaborative projects between the Inflammation biology lab, academics, and industry (vaccines, anti-virals, treatments of viral-induced immunopathology, and basic molecular virology), his main research projects currently are:
- Establishing various in vitro models and mouse models for SARS-CoV-2 and COVID-19 to investigate virus-host interactions, innate immune responses, immunopathology, and to test interventions.
- Characterising the role of host proteins in Chikungunya virus infection and immunopathology, including granzyme A
- The role of microplastic consumption in viral-induced immunopathology
- Effect of virus infection on gut microbiome and its link to immunopathology
- Investigating alphavirus species tropism using in vitro models by probing virus-host interactions, innate immune responses, and virus adaptation to host
RESEARCH HIGHLIGHTS
- Helped establish a PC3 laboratory for SARS-CoV-2/COVID-19 research at QIMR during the 2020 pandemic
- Involved in projects showing efficacious vaccine candidates against Zika virus, Yellow Fever virus, and Chikungunya virus in mouse models of infection and disease (all published in Vaccines, 2020)
- Identified small molecule inhibitors of a virus-host interaction in HIV infection (Journal of Virology, 2019), leading to a provisional patent
- Characterised an important HIV-host interaction in molecular detail and characterised its role in HIV replication (mBio 2018 and PLoS Pathogens 2015)
- Showed early innate immune responses to West Nile virus in monocyte-derived dendritic cells may be indicative of their difference in virulence for humans (Virology Journal, 2015)
PROFESSIONAL MEMBERSHIPS
2015-current: Australian Virology Society member
2020-current: QIMR Berghofer Postdoctoral Committee member, career development sub-committee
2018-2019: Australian Society of Microbiology member
2016: President of QIMR Berghofer Student Society
2016: Executive member of QIMR Staff Association – Student Representative
AWARDS RECOGNITION
2018: QIMR Berghofer Travel Award
2017: ViiV Healthcare Student Award – Australian Virology Society conference 2017
2016: QIMR Berghofer Top-Up Award
2015: QIMR Berghofer Student Symposium – early postgraduate runner up
2015: Australian Postgraduate Award (APA) PhD scholarship
2014: Dean’s Commendation for Academic Excellence (Honours)
2013: Dean’s Commendation for High Achievement (Undergraduate)
EDUCATIONAL BACKGROUND
2015-2019: Doctor of Philosophy (PhD), The University of Queensland, School of Chemistry and Molecular Biosciences and QIMR Berghofer Medical Research Institute
2011-2014: Bachelor of Science (Honours), The University of Queensland, School of Chemistry and Molecular Biosciences