Our People

Carolina Soekmadji

Dr | Senior Research Officer

Hepatic Fibrosis

Carolina.Soekmadji@qimrberghofer.edu.au

CAREER HISTORY

Dr Carolina Soekmadji is a biomedical scientist that passionate about developing treatment strategy for advanced cancer. She is an expert in the field of Extracellular Vesicles (EVs), lipid bubbles that contain messenger molecules and mediate communication with their neighbouring cells and distant organs. Her work is aimed to identify early response to drugs and alternative treatment strategies.

She highlighted that a subpopulation of small EVs, the CD9 positive EVs, can stimulate cell proliferation and increased survival in prostate cancer. Her current work has focused on the effect of androgens on EV cargo such as proteins, small RNAs and lipids, to identify biomarkers that can indicate treatment response for patients under androgen deprivation therapy (ADT). She is the PI on two grants awarded by the United States Department of Defense Prostate Cancer Research Program (2012-2014, as  the only Australian out of 30 international awardees and from 2017-2020 the only non-US awardee out of 9 recipients).

Dr. Soekmadji was a junior co-leader of international collaborative projects through Movember Global Action Plan and the Movember Revolutionary Team Awards (2012-2016). In 2016, she was elected as the only junior member on the Board of Directors Members-at-large for the only global society in the field of EVs, the International Society of Extracellular Vesicles (ISEV, 2016-2020). Her leadership is further demonstrated by invitations as a plenary speaker at overseas meetings and workshops, chairs sessions at international conferences/workshops. Dr Soekmadji led the development of  online course Massive Online Open Course (MOOC) ‘EVs in Health and Diseases’ (54 experts, >2500 students in September 2020). In July 2020, she was awarded the highly prestigious ISEV Special Education Award for her role in leading the MOOC. She has recently founded the WebEVTalk series on March 2020, a regular talk series for EV enthusiasts around the globe (profiled in journal Trillium Extracellular Vesicles, YouTube link here). The WebEVTalk series have been widely popular and featuring many international experts in the field of EVs.

 

ORCID NUMBER   

0000-0002-6920-6627 

 

RESEARCHER ID      

M-2757-2016

 

CURRENT AREA OF RESEARCH

  • Extracellular vesicles
  • Exosomes
  • Prostate cancer
  • Cancer Biomarker
  • Cancer therapy
  • Personalised Medicine

RESEARCH GRANTS

2017 present: Department of Defense US Army Prostate Cancer Program Idea Development Award

2016: Movember Revolutionary Team Award 3

2012 – 2015: Movember Global Action Plan 1 for Exosome Biomarker

2012 – 2014: Department of Defense US Army Postdoctoral Training Award

CURRENT COLLABORATIONS

  • Prof Grant Ramm, Queensland Institute of Medical Research, Brisbane, Australia
  • Prof Guido Jenster, Erasmus MC, Rotterdam, Netherland
  • Dr Elena Martens-Uzunova, Erasmus MC, Rotterdam, Netherland
  • Dr Marzia Del Re, University of Pisa, Italy
  • Prof Andrew Hill, La Trobe University, Melbourne, Australia
  • AProf Rebecca Lim, Monash University, Melbourne, Australia
  • Prof Takahiro Ochiya, Tokyo Medical University, Japan 

 

PHD AND MASTERS OPPORTUNITIES

Please contact Carolina to learn more about opportunities for PhD and Masters students to work with the Institute.

 

RESEARCH HIGHLIGHTS

She highlighted that the EV marker CD9, through its delivery to target cells via EVs, can stimulate cell proliferation and increased survival in prostate cancer. Her current work has focused on the effect of androgens on RNA cargo of EVs to identify biomarkers that can indicate treatment response for patients under hormonal therapy for prostate cancer. Dr Soekmadji is currently developing a new EV-based therapeutic strategy for advanced prostate cancer.

 

AWARDS RECOGNITION

2020: ISEV Special Education Award
2017: The United States Department of Defense Prostate Cancer Research Program Idea Development Award (New Investigator)
2012-2014: The United States Department of Defense Prostate Cancer Research Program PCRP Postdoc Training Award
2014: Best poster at 2014 ISEV conference
2011: First prize for poster presentation at the 1st Australasian Prostate Cancer Conference
2007: Graduate/Postdoctoral Travel Awards (American Society for Biochemistry and Molecular Biology, USA)
2007: Melbourne Abroad Travelling Scholarship
2004-2007: Melbourne International Research Scholarship
2004-2007: International Postgraduate Research Scholarship
1999-2002: Panasonic Scholarship (Matsushita Electric Industrial Co., Ltd, Japan)

 

EDUCATIONAL BACKGROUND

2009: PhD, Department of Genetics, The University of Melbourne, Australia
2002: Master of Science, Graduate School of Agriculture, Division of Applied Life Science, Laboratory of Applied Structural Biology, Kyoto University, Japan
1998: Sarjana in Agricultural Technology, Food Science and Engineering, Bogor Agricultural University, Indonesia