Mosquito Genomics

Dr Gordana Rašić

Senior Research Fellow & Team Head

Better control of mosquito-borne diseases through mosquito genomics:

New technologies to control mosquitoes and diseases they transmit are developing rapidly – from the natural pathogen-blocking symbiotic bacteria to the engineered “selfish genes”. In creating and assessing new mosquito control technologies, we take the approach “from the field – to the lab – back to the field”.

This means that we study natural mosquito populations, do laboratory experiments, and aim to produce practical solutions for field deployment. In doing so, we generate and analyse genomic and other “omics” data from a single mosquito cell to a system of mosquito populations.

We use genomics to understand how mosquitoes move, mate and survive in different environments so that we can find optimal control strategies (spatial population genomics, simulation modelling), and to identify new targets for genetic control (molecular biology).

We collaborate with the leading scientists in Australia, USA, Asia-Pacific and Europe to address the current challenges and predict future obstacles in protecting the communities in Queensland, Australia and around the globe from the mosquito-borne diseases.

Mosquito genomics the main vector of deadly diseases like yellow fever and dengue

Aedes aegypti – the main vector of deadly diseases like yellow fever and dengue

CURRENT RESEARCH

  • Development of tools for innovative mosquito surveillance (close‑kin mark‑recapture methods to estimate mosquito demography and movement)
  • Population and landscape genomics of arboviral and malaria mosquito vectors
  • Optimization of Wolbachia-based programs
  • Frameworks for the implementation of gene drive technology to control mosquito‑borne diseases
  • New gene targets for the control of arbovirus and malaria vectors
  • Development of mosquito genomic resources (genome assemblies and annotations, analytics workflows)
  • Development of a biosecurity platform for exotic mosquitoes
  • Dengue
  • Zika
  • Malaria
  • Ross River Fever
  • Japanese Encephalitis

Staff

Internal Collaborators

  • Mosquito Control Laboratory

 External Collaborators

  • John M Marshall (University of California, Berkeley)
  • Louis Lambrechts (Institut Pasteur, Paris)
  • Environmental Health Institute (National Environment Agency, Singapore)
  • Brendan Trewin (CSIRO)
  • Nigel Beebe (University of Queensland and CSIRO)
  • Jennifer Bannan (Brisbane South State Secondary College)
  • Hervé Bossin (Institut Louis Malardé, French Polynesia)
  • Francoise Mathieu-Daude (Institute of Research for Development, France)
  • Tanking Widarsa (Warmadewa University, Bali, Indonesia)

We gratefully acknowledge support from:

  • National Institutes of Health (NIH)
  • National Health and Medical Research Council (NHMRC)
  • Office of the Queensland Chief Scientist, Queensland Government

PUBLICATIONS & PRE-PRINTS

VIDEOS

 

Aedes aegypti in action

 

Mosquito sperm cells in action – single cells are being sequenced to find good gene-drive targets

STUDENT PROJECTS

No Student Projects