Cellular & Molecular Neurodegeneration

The Cellular and Molecular Neurodegeneration Laboratory investigates the cause and potential treatments for brain diseases including dementia (Alzheimer’s disease), motor neuron disease (amyotrophic lateral sclerosis) and Parkinson’s disease. These disorders (collectively known as neurodegenerative diseases) are a growing health issue in Australia and worldwide, with few treatment options available. In order to gain a better understanding of these diseases and develop new therapeutic approaches, the research team is currently developing new human brain cell culture methods for microglia, brain endothelial cells, organoids (mini-brains), and olfactory (nasal) cells.

The lab is utilising these new 2D and 3D human brain cell models to understand brain disease pathways, and the impact of environmental factors such as air pollution, SARS-CoV-2, and bushfire smoke on brain health. We have also established platforms for drug screening to identify potential new therapeutics for treatment of brain diseases.

CURRENT RESEARCH

  • 2D and 3D culture models of human microglia from Alzheimer’s disease, motor neuron disease and Parkinson’s disease
  • 2D and 3D cultures models of the blood-brain barrier
  • organoid (mini-brain) models of Alzheimer’s disease
  • olfactory (nasal) cell models of Alzheimer’s disease
  • impact of bushfire smoke and other forms of air pollution on brain health and disease
  • development of an olfactory cell assay for bushfire smoke impact on human health
  • improving drug delivery with focused ultrasound to transiently open the blood brain barrier
  • development of novel metal-drugs for treatment of neurodegenerative diseases

Staff:

Internal Collaborators:

External Collaborators:

  • Dr Katja Kanninen & Dr Tarja Malm, A.I. Virtanen Institute, Kuopio, Finland
  • Dr Lezanne Ooi, Illawarra Health and Medical Research Institute
  • Professor Alan Mackay-Sim, Griffith University
  • Professor Vincenzo La Bella, University of Palermo
  • Dr Alexandra Grubman, Monash University
  • Dr Alex Cristino, Griffith University
  • Dr Luke Knibbs, University of Queensland
  • Professor Zoran Ristovski, Queensland University of Technology
  • Professor Jari Koistinaho, Helsinki University
  • Professor Juergen Goetz, Queensland Brain Institute
  • Professor Sandra Hodge, The University of Adelaide
  • Dr Fabienne Reisen, CSIRO
  • Dr Luana Main, Deakin University
  • Dr Jeffrey Liddell & Dr Peter Crouch, Department of Pathology, University of Melbourne
  • Professor Ashley Bush & Professor Colin Masters, Florey Institute of Neuroscience and Mental Health
  • Professor Paul Donnelly, School of Chemistry and Bio21 Institute, University of Melbourne
  • NHMRC
  • MRFF
  • Motor Neuron Disease Research Australia (MNDRA)
  • FightMND Foundation

3D view of a human microglia grown in culture

Interaction between human microglia (green) and neurons (red) in 3D culture

Human brain astrocytes growing in culture