Translational & Human Immunology

The major focus of the Translational and Human Immunology group is to delineate the mechanisms that regulate human immune responses in health and disease. Knowledge gained from these studies forms the basis for developing novel immune interventional and diagnostic strategies that can implemented in clinical settings. The group is also interested in understanding the transcriptional and epigenetic regulation of human immune responses during persistent viral infections and human cancers, and in developing strategies to manipulate this regulation to improve outcomes following immune intervention.

  • developing novel T cell immunotherapies to treat viral diseases, emerging pathogens and cancer
  • understanding the attributes of T cell immunotherapy that improve therapeutic outcome
  • exploring T cell dysfunction in immunocompromised patients and its impact on infectious complications
  • characterising T cell immunity to SARS-CoV-2 and the impact of immune senescence.

CURRENT RESEARCH

  • developing novel T cell immunotherapies to treat viral diseases, emerging pathogens and cancer
  • understanding the attributes of T cell immunotherapy that improve therapeutic outcome
  • exploring T cell dysfunction in immunocompromised patients and its impact on infectious complications
  • characterising T cell immunity to SARS-CoV-2 and the impact of immune senescence

Internal Collaborators

  • Professor Rajiv Khanna AO
  • Professor Sudha Rao
  • Professor Mark Smyth
  • Associate Professor Michelle Wykes