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Translational & Human Immunology

Associate Professor Corey Smith

Group Leader

The major focus of the Translational and Human Immunology group is to delineate the mechanisms that regulate human immune responses in health and disease. Knowledge gained from these studies forms the basis for developing novel immune interventional and diagnostic strategies that can implemented in clinical settings. The group is also interested in understanding the transcriptional and epigenetic regulation of human immune responses during persistent viral infections and human cancers, and in developing strategies to manipulate this regulation to improve outcomes following immune intervention.

  • developing novel T cell immunotherapies to treat viral diseases, emerging pathogens and cancer
  • understanding the attributes of T cell immunotherapy that improve therapeutic outcome
  • exploring T cell dysfunction in immunocompromised patients and its impact on infectious complications
  • characterising T cell immunity to SARS-CoV-2 and the impact of immune senescence.

CURRENT RESEARCH

  • developing novel T cell immunotherapies to treat viral diseases, emerging pathogens and cancer
  • understanding the attributes of T cell immunotherapy that improve therapeutic outcome
  • exploring T cell dysfunction in immunocompromised patients and its impact on infectious complications
  • characterising T cell immunity to SARS-CoV-2 and the impact of immune senescence

Staff

  • Katie Lineburg, Senior Research Officer
  • Kiana Berry, PhD Student
  • Lea Lekieffre, Research Assistant
  • Oyime Poise Aula, Research Officer
  • Swathi Muralidhar, PhD Student

Internal Collaborators

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STUDENT PROJECTS

Detection of Epstein – Barr virus (EBV) in healthy volunteers

Background Epstein – Barr virus (EBV), a ubiquitous herpesvirus, establishes lifelong latent infections in more than 90% of adults. While most infections remain asymptomatic, periodic viral shedding, particularly in saliva, facilitates transmission. This phenomenon could be linked to EBV reactivation and its role in diseases like multiple sclerosis (MS) and certain cancers. Despite its importance, […]

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EBV, where are you hiding?

This project is suitable for an Honours students. Background: Epstein Barr Virus (EBV) is a common human viral infection that is most well known as the cause of infectious mononucleosis/glandular fever. Following acute exposure, EBV establishes lifelong latent infection in B cell lymphocytes with periodic stages of reactivation that lead to viral shedding. While benign […]

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