Clinical Malaria

The focus of the Clinical Malaria Group is the evaluation of the safety and efficacy of candidate antimalarials, using the induced blood stage malaria (IBSM) model in healthy human volunteers.  Developed by the previous group lead Professor James McCarthy, the model has been used to evaluate 10 investigational medicinal products.  Models have been established for an artemisinin-sensitive and an artemisinin-resistant P. falciparum strain, and other Plasmodium species including P. vivax and P. malariae.  The model has also enabled the conduct of studies to evaluate transmission-blocking interventions, and has enabled the conduct of exploratory studies to evaluate immunological and pathophysiological response to infection.


  • Clinical trials to evaluate candidate antimalarials
  • Using the IBSM model to improve understanding of the pathogenesis of malaria
  • Adam Potter, Medical Writer
  • Arya Sheela Nair, Research Assistant
  • Azrin Abd-Rahman, Pharmacometrician
  • Dean Andrew, Research Assistant
  • Dr Fiona Amante, Laboratory Manager
  • Helen Jennings, Quality Manager
  • Jenny Peters, Scientific Officer
  • Jeremy Gower, Research Assistant
  • John Woodford, Visiting Scientist
  • Katharine Trenholme, Senior Research Fellow
  • Louise Marquart, Affiliate
  • Dr Rebecca Webster, Clinical Operations Manager
  • Ria Woo, Senior Clinical Data Manager
  • Sean Lynch, PhD Student
  • Sumudu Britton, Affiliate

We gratefully acknowledge support from the following organisations and funding bodies

  • The Medicines for Malaria Venture
  • The Bill and Melinda Gates Foundation