The Australian Defence Force Malaria and Infectious Disease Institute Laboratory was established to facilitate and enhance research collaborations between QIMR Berghofer and the Army Defence Force Malaria Infectious Disease Institute (ADFMIDI). Our research focuses on investigating the biological and molecular changes in malaria parasites that makes them difficult to detect and/or resistant to anti-malarial drugs, and the epidemiological surveillance of these parasites. Our findings inform malaria diagnosis and treatment policies for improving public health and defence force health protection.