A major focus of the Lung Inflammation and Infection program is to investigate the interaction between bacterial pathogens and the host innate immune response within the lung. Chronic respiratory diseases characterised by infection are prevalent in Australia and globally. The group are studying the role of iron and other biologically active metal ions in promoting bacterial infection in the lungs of patients with the genetic disease cystic fibrosis (CF) and other suppurative lung diseases. To do this the group is studying bacterial and host immune system interactions in vivo using a number of biochemical, molecular and cell imaging methods and also modelling these interactions using mouse models. They are developing molecules to interfere with bacterial iron acquisition with the goal of developing these as antibiotic adjuncts.