The Signal Transduction Laboratory researches DNA damage signalling and repair pathways and their impact on cancer susceptibility through preventing DNA mutations. These studies have significant relevance to both basic biology (e.g. understanding the process of cell division, repair of DNA damage and mechanisms of ageing) and clinical medicine (e.g. effect on drug efficacy).
Several genes involved in the DNA damage response pathways are known to contribute to breast cancers. This group seeks to identify other known or new genes in these pathways which might have similar involvement in cancer susceptibility by preventing mutations in our DNA. This area is of critical importance to cancer research as the pathway controlling the DNA damage response are involved in tumour suppression and are believed to be mutated at the early stage in the evolution of cancer.
We gratefully acknowledge financial support of