The Immunopathology Laboratory is focussed on understanding the cellular and molecular mechanisms that drive immune-mediated pathologies. Our recent focus is on adaptive immune polarisation following allogeneic stem cell transplantation and its influence on graft versus host disease (GVHD). Donor stem cell transplantation is an important curative therapy in the treatment of blood cancers, however its application is limited by serious complications such as GVHD that have a significant impact on patient mortality and quality of life.

Early inflammatory responses during preparative transplant conditioning initiate a cascade of adaptive immune responses that manifest as acute and/or chronic tissue damage in >50% of transplant recipients. GVHD treatment options are relatively limited and focused on immunosuppression and steroidal therapy, which are problematic due to opportunistic infection and refractory disease, therefore new therapies are urgently needed.


  • Cytokine responses in the gastrointestinal tract dictate stem cell transplant outcome
  • IL-5 dysregulation early after allo-SCT: a new approach to GVHD prevention
  • RORgt inhibition as a novel therapeutic for the prevention of graft-versus-host disease after allogeneic stem cell transplantation


  • Karshing Chang, Research Assistant
  • Dr Andrea Henden, Student
  • Alison Wang, Student

Internal Collaborators

External Collaborators

  • Professor Geoffrey Hill, Fred Hutchinson Cancer Research Center, USA
  • Professor Joseph Trapani, Peter MacCallum Cancer Centre
  • Dr Julie Spicer, University of Auckland, New Zealand
  • Dr Ruby Law, Monash University
  • Cancer Council Queensland


Boosting immune checkpoint regulation to prevent/limit GVHD after allotransplantation

Suitable for Honours, PhD and clinical Students. Background: Complement Receptor of the Immunoglobulin family (CRIg) is a relatively recently described molecule, which binds complement fragments C3b, iC3b and C3c and is expressed by tissue resident macrophage populations. CRIg plays an important role in hepatic clearance of complement opsonised pathogens, and can also regulate the alternative […]

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Characterising miRNA expression after bone marrow transplantation to develop novel therapeuti

Suitable for Honours, PhD and Clinical Students. Background: Micro RNAs (miRNAs) are small RNA molecules (~25 nucleotides) known to play an important role in regulating inflammation and therefore may be a novel target to treat inflammatory diseases. This project will investigate the potential for miRNAs as biomarkers of disease and as novel therapeutics to modulate […]

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Modulating donor T cell polarisation after bone marrow transplantation to prevent graft-versus-host disease

Suitable for Honours, PhD and clinical Students. Background: Donor T cell polarization is a critical factor influencing the severity and tissue distribution of graft-versus-host disease (GVHD) and the potency of graft-versus-leukaemia (GVL) effects after allo-SCT. We have identified a pathogenic donor T cell differentiation program that exacerbates GVHD without contributing to tumour clearance, which is […]

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