The Functional Cancer Genomics Laboratory focuses on understanding how DNA variation contributes to cancer risk and development. The laboratory is particularly interested in translating the findings from cancer genome-wide association studies (GWAS). This includes identification of the functional risk variants, connecting these variants to their target genes and understanding how the new genes contribute to cellular phenotypes. Our research integrates genetics, chromatin and transcriptome profiling, computational genomics and molecular studies to unravel the complexity of cancer development. These discoveries have accelerated progress from genetic studies to biological knowledge that may ultimately guide preventative and therapeutic measures.