Antigen Presentation & Immunoregulation

Dr Kelli MacDonald

Group Leader

The Antigen Presentation and Immunoregulation Laboratory investigates the contribution of donor and host antigen presenting cells (APCs) to immune responses following bone marrow stem cell transplantation. Basic research in immunology using preclinical models follows three streams: APC development, antigen presentation, and APC induced T cell responses and their regulation.

CURRENT RESEARCH

  • Role of IL-17 and related family members in fibrosis – chronic GVHD and chronic liver disease
  • Role of macrophages in GVHD
  • Contribution of regulatory T cells to the development of chronic GVHD
  • Role of autophagy in stem cell transplantation
  • Metabolic profiling of T cells in cGVHD

Staff

  • Dr Laetitia Le Texier, Research Officer
  • Dr Michelle Melino, Research Officer
  • Katie Lineburg, PhD Student
  • Jemma Nicholls, PhD Student
  • Christina Nalkurthi, PhD Student
  • Bianca Teal, Research Assistant
  • Justin Rich, Research Assistant

Internal Collaborators

External Collaborators

  • Professor Geoff Hill, Fred Hutch Cancer Research Center, Seattle
  • Professor Ranjeny Thomas, Diamantina Institute, University of Queensland
  • Professor David Hume, The Roslin Institute, University of Edinburgh
  • Dr Gabrielle Belz, Dr Christine Wells & Dr Jose Villandangos, Walter and Eliza Hall Institute
  • Professor Bruce Blazar, University of Minnesota
  • Dr Andrew Clouston, Envoi Pathology
  • Dr Allison Pettit, UQCCR University of Queensland
  • Dr Justine Mintern, University of Melbourne
  • Dr Patrick Bertolino, Centenary Institute

We gratefully acknowledge the support of the following funding agencies

  • National Health and Medical Research Council
  • Cancer Council Queensland
  • Leukaemia Foundation Australia
  • The Atlantic Philanthropies
  • Rio Tinto Ride to Conquer Cancer Flagship