Epigenetic modifications change the pattern of expression in genes. In some cases, this can give rise to cancers. The group research uses small molecule inhibitors to reverse some of these changes and block tumour progression. Having successfully identified combinations of epigenetic modifying enzyme inhibitors that stop the growth of tumour cell lines – making the more sensitive to clinical treatments or reversing the resistance of some cancers to some therapies – the group is now testing these combinations in animal models. The epigenetic studies target breast, ovarian, head and neck and lung cancers as well as melanoma.