Clinical Genomics

The Clinical Genomics Laboratory uses computational analysis of cancer genomics data to characterise and investigate cancers at the molecular level to identify genomic attributes that can affect cancer patient clinical health outcomes. The team of bioinformaticians work across multiple different cancer types and have extensive experience in the analysis and interpretation of cancer genomics sequencing data, including whole-genome and whole-exome sequencing, single-cell and tumour transcriptomics and methylomics. The main research focus is to understand the effects of intra-tumour heterogeneity on cancer treatment response.


Through partnership with clinicians and researchers, the Clinical Genomics Laboratory tackles a wide range of projects –

  • genomic characterisation of malignant pleural mesothelioma
  • genome-wide CpG methylation in malignant pleural mesothelioma
  • multi-sample heterogeneity analysis of colorectal cancer
  • colorectal cancer transcriptome analysis
  • in silico identification of neoantigens in follicular lymphoma samples
  • identification of targetable somatic mutations in sinonasal undifferentiated carcinomas
  • intratumour heterogeneity in PDX models of endometrial cancer

Our Staff

  • Dr Pamela Mukhopadhyay, Research Officer
  • Dr Stephen Kazakoff, Bioinformatician

Internal Collaborators

External Collaborators

  • Professor Maher Gandhi, University of Queensland/Mater Hospital
  • Professor Sandro Porceddu, University of Queensland/Princess Alexandra Hospital
  • Associate Professor Pamela Pollock, Queensland University of Technology
  • Professor Sian Ellard, University of Exeter Professor
  • Andrew Hattersley, University of Exeter
  • National Health and Medical Research Council (NHMRC)
  • Philanthropic donation for malignant pleural mesothelioma


No Student Projects