Cancer Genetic Susceptibility

The Cancer Genetic Susceptibility laboratory primarily studies the role of genetics in endometrial cancer risk and development. Our team leads large-scale genetic studies for endometrial cancer and uses these data to answer a variety of research questions falling under three main themes: prevention, prediction and treatment.

CURRENT RESEARCH

  • Genome-wide association studies of endometrial cancer
  • Identification of causal risk factors or modifiable factors for cancer
  • Endometrial cancer risk prediction model development
  • Endometrial cancer risk gene identification, through computational analysis and wet-lab experiments
  • Identification of novel therapeutic targets for endometrial cancer

Staff

  • Bianca Naumann, Research Assistant
  • Carly Chapman, Research Assistant
  • A/Prof Dylan Glubb, Senior Research Officer
  • Matthew Barker, Research Officer
  • Serena Gallozzi, Research Officer
  • Wenhan Chen, Research Officer
  • Dr Xuemin (Patrick) Wang, Research Officer

Internal Collaborators

  • Prof Amanda Spurdle
  • A/Prof Jonathan Beesley
  • Prof Georgia Trench
  • Prof Penny Webb

 External Collaborators

  • ECAC collaborators (Endometrial Cancer Association Consortium) ecac-studies.org
  • BCAC consortium (Breast Cancer Association Consortium) http://apps.ccge.medschl.cam.ac.uk/consortia/bcac/
  • Dr Marc Gunter & Dr Laure Dossus, International Agency for Research on Cancer – World Health Organisation
  • Professor Emma Crosbie, University of Manchester
  • Associate Professor Caroline Ford, University of New South Wales
  • Associate Professor Logan Walker, University of Otago
  • Associate Professor Jason Gertz, Huntsman Cancer Institute
  • Professor Hugo Vankelecom, KU Leuven University
  • NHMRC
  • Worldwide Cancer Research
  • Cancer Australia
  • HRC New Zealand

STUDENT PROJECTS

Genetic epidemiology of endometrial cancer

Suitable for PhD students only. BACKGROUND Endometrial cancer is the most commonly diagnosed invasive gynaecological cancer in developed countries. In contrast with many cancers, the incidence and mortality of endometrial cancer is steadily increasing, largely due to increasing rates of obesity, the strongest risk factor for this disease. Through leadership of the Endometrial Cancer Association […]

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Identifying the regulatory targets of common endometrial cancer risk variants

Can be adapted in scope for Honours or PhD student. BACKGROUND We and our international Endometrial Cancer Association Consortium collaborators have identified common genetic variation at 16 genomic regions that associates with endometrial cancer risk. Although we have identified potentially causal risk variants, at most regions we do not know which genes these variants target. […]

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