Leukaemia Metabolism


Dr Claudia Bruedigam

Team Head

The Leukaemia Metabolism Laboratory investigates topics at the interface of oncology, immunology and biochemistry with a focus on Acute Myeloid Leukaemia (AML), a very aggressive and rapidly fatal disease. 


Current Research

A major aspect of its research program is the development of humanised mouse models using patient samples, normal cord blood or bone marrow-derived stem cells and recently engineered, improved recipient mouse strains to model systemic disease. We apply integrated omics profiling and single cell sequencing in combination with CRISPR/Cas9-mediated gene editing to characterise the molecular responses to standard and novel therapies. Specifically, the lab investigates the role of lipid desaturation and ferroptosis in leukaemic stem and immune cell compartments, and aims to identify metabolic vulnerabilities that can be exploited to develop novel, effective therapies for AML.


  • Amy Porter
  • Elisa Lim
  • Eunice Dulatre
  • Laura Bray


Metabolism-Focused Preclinical Development of Therapies for Acute Myeloid Leukaemia

Suitable for Honours and PhD students. BACKGROUND Acute myeloid leukaemia (AML) is an aggressive and lethal blood cancer with a 5-year overall survival of less than 45% for patients younger than 60 years of age, or less than 10% for older patients. In Australia, about 1,000 patients are newly diagnosed with AML each year, and […]

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