The overarching theme of the Mucosal Immunology Laboratory is to promote immune regulation in order to control inappropriate immune responses responsible for allergy and autoimmune diseases. We utilise experimental, preclinical, and computational approaches to develop novel therapeutic strategies that translate into preventative or therapeutic interventions.
- Ferreira IB, Pickering DA, Troy S, Croese J, Loukas A, and Navarro S, Suppression of inflammation and tissue damage by a hookworm recombinant protein in colitis. Clin Transl Immunology1038/cti.2017.42
- Sotillo J, Ferreira IB, Potriquet J, Laha T, Navarro S, Loukas A, and Mulvenna J (2017) Change in protein expression after treatment with Ancylostoma caninum excretory/secretory products in a mouse model of colitis, Sci Rep1038/srep41883
- Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, and Loukas A (2016) Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma, Sci Trans Med1126/scitranslmed.aaf8807
- Giacomin P, Zakrzewski M, Croese J, Su X, Sotillo J, McCann L, Navarro S, Mitreva M, Krause L, Loukas A, and C Cantacessi (2015) Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects, Sci Rep1038/srep13797
- Liu T, Navarro S, and Lopata AL (2015) Current advances of murine models for food allergy, Mol Immunol 10.1016/j.molimm.2015.11.011
- Determine the composition of AIP-2-shaped breastmilk and define the microbiome, metabolome and immune landscape of AIP-2-nursed pups
- Influence of parasite infection on microbiome and metabolite composition in mother/baby dyads from hookworm endemic areas
- Tolerance induction with a hookworm protein and prevention/treatment of allergic asthma
- Development of a hookworm recombinant protein for the suppression of allergic responses
- Determine the role of microbiome, immune factors and short-chain fatty acids in AIP-2-induced tolerance
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