The HIV and Molecular Virology Laboratory analyses human immunodeficiency virus (HIV) replication. This includes the process by which HIV is able to convert its genetic material composed of RNA into a form compatible with human DNA. Our focus is the discovery of key viral or cellular molecules required for HIV to grow, and then to target their action so that HIV growth can be effectively blocked. The lab is also interested in cellular factors regulating respiratory syncytial virus (RSV) and Dengue virus replication.
Group Leader: Associate Professor David Harrich
- Daniel Rawle, PhD Student
- Mary Lor, Research Assistant
- DongSheng Li, Research Officer
- HongPing Jin, Research Officer
- Lu Wang, Student
- Min-Hsuan Lin, Research Officer
Selected Key Publications
- HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.
Rawle DJ, Li D, Swedberg JE, Wang L, Soares DC, Harrich D.
- RNA glycosidase and other agents target Tat to inhibit HIV-1 transcription.
Harrich D, Jin H.
- Differential Effects of Strategies to Improve the Transduction Efficiency of Lentiviral Vector that Conveys an Anti-HIV Protein, Nullbasic, in Human T Cells.
Rustanti L, Jin H, Li D, Lor M, Sivakumaran H, Harrich D.
- A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes.
Rustanti L, Jin H, Lor M, Lin MH, Rawle DJ, Harrich D.
- Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein.
Jin H, Li D, Sivakumaran H, Lor M, Rustanti L, Cloonan N, Wani S, Harrich D.
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