Though all genes exist within every cell in the human body, only a defined gene expression program is executed at any time via reprogramming of the epigenome in response to environmental cues. These dynamic events are elegantly orchestrated by writer and eraser enzymes; generating a ‘histone code’ within the epigenetic landscape of genes. The therapeutic implications of targeting novel domains of epigenetic enzymes are beginning to be appreciated in immuno-oncology. My laboratory’s focus on immune-oncology is on metastatic cancers and potential implications for viral therapy and the immune response in the aged population. My lab’s work is also addressing the potential implications for the utility of epi-therapy in combination with immunotherapy and chemotherapy for a variety of metastatic cancers. My team is also in the process of developing sensitive liquid biopsies using our newly identified novel biomarkers for patient responsiveness to immunotherapy in the context of the tumour microenvironment. We are also in the process of developing clinical based epigenetic platforms for drug screening and biomarker discovery in collaboration with global technology partnerships.
Group Leader: Professor Sudha Rao
- Dr Robert McCuaig, Research Officer
- Dr Sherry Tu, Research Officer
- Dr Amanda Bain, Research Officer
- Jenny Dunn, Research Assistant
- John Vandermeide, Honours Student
- Zhane Anderson, Honours Student
- Dr Thiru Prasanna, PhD Student & Oncologist
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer. Tan AHY, Tu W, McCuaig R, Hardy K, Donovan T, Tsimbalyuk S, Forwood JK, Rao S. Front Immunol. 2019 Jun 12;10:1351. doi: 10.3389/fimmu.2019.01351. eCollection 2019.
Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer. Wu F, McCuaig RD, Sutton CR, Tan AHY, Jeelall Y, Bean EG, Dai J, Prasanna T, Batham J, Malik L, Yip D, Dahlstrom JE, Rao S.Int J Mol Sci. 2019 Jun 24;20(12). pii: E3080. doi: 10.3390/ijms20123080. Dual Specificity Phosphatases Special issue on IJMS
LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Boulding T, McCuaig RD, Tan A, Hardy K, Wu F, Dunn J, Kalimutho M, Sutton CR, Forwood JK, Bert AG, Goodall GJ, Malik L, Yip D, Dahlstrom JE, Zafar A, Khanna KK, Rao S. Sci Rep. 2018 Jan 8;8(1):73. doi: 10.1038/s41598-017-17913-x.
Epigenetic programming of T cells impacts immune reconstitution in hematopoietic stem cell transplant recipients. Hardy K, Smith C, Tu WJ, McCuaig R, Panikkar A, Dasari V, Wu F, Tey SK, Hill GR, Khanna R, Rao S. Blood Adv. 2018 Mar 27;2(6):656-668. doi: 10.1182/bloodadvances.2018015909.
Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function. Russ BE, Olshansky M, Li J, Nguyen MLT, Gearing LJ, Nguyen THO, Olson MR, McQuilton HA, Nüssing S, Khoury G, Purcell DFJ, Hertzog PJ, Rao S, Turner SJ. Cell Rep. 2017 Dec 19;21(12):3624-3636. doi: 10.1016/j.celrep.2017.11.097.
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