The Functional Cancer Genomics Laboratory focuses on understanding how DNA variation contributes to cancer risk and development. The laboratory is particularly interested in translating the findings from genome-wide association studies (GWAS) for breast, ovarian, endometrial, prostate and skin (melanoma) cancers. This includes identification of the causal risk variants, connecting these variants to their target genes and understanding how the new genes contribute to cellular phenotypes associated with cancer development. We have already identified several molecular pathways that were not known to play a role in cancer that are suitable targets for drug repositioning or drug development. The ultimate aim of our research is to pave the way for future clinical trials for cancer prevention or treatment.
Team Head: Associate Professor Stacey Edwards
- Kristine Hillman, Research Assistant
- Susanne Kaufmann, Research Assistant
- Dr Haran Sivakumaran, Research Officer
- Post-GWAS functional characterisation of breast cancer susceptibility loci
- Identifying new long-noncoding RNAs involved in breast cancer development
- Identification and evaluation of new breast cancer genes.
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