The Clinical Tropical Medicine (CTM) Laboratory is a research group led by Professor James McCarthy within QIMR Berghofer Medical Research Institute in Brisbane, Australia.
CTM aims to improve human health by contributing to the control of human parasitic diseases, particularly malaria. The main research themes of CTM are:
- To evaluate the safety and activity of candidate antimalarial drugs and vaccines using the Induced Blood Stage Malaria (IBSM) model
- To investigate the biology of malaria parasites
- To investigate other parasitic tropical diseases, specifically scabies and helminth infections.
CTM has developed an IBSM model to evaluate the safety and activity of candidate antimalarial drugs and vaccines. This model has shortened the time required to clinically evaluate candidate antimalarials. During 2017, CTM extended the IBSM model to evaluate transmission-blocking interventions and antimalarial chemoprophylactic drugs, as well as developed master cell banks and systems to study artemisinin-resistant P. falciparum and for other Plasmodium species.
Professor James McCarthy’s complete list of publications can be viewed at his National Center for Biotechnology Information (NCBI) bibliography page.
- Investigation of co-infection dynamics between P. falciparum and P. knowlesi
- Investigating the OPG/RANKL/TRAIL pathway in malaria
- Investigation of malaria parasite viability after drug treatment in vitro and in humans
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