- 13 June 2019
1:00 pm - 2:00 pm
Thursday 13 june 2019, 1.00 PM
Auditorium, Level 6, Bancroft Building
Hype and reality in human geneticS
Professor Georgia Chenevix-Trench
QIMR Berghofer Medical Research Institute
Genome-wide association studies have identified 1000s of loci associated with risk of every complex trait studied, from the propensity to tears to age of onset of Huntington’s disease. A major aim of post-GWAS studies is to translate their findings into molecular mechanisms, in order to understand the underlying biology and ultimately develop more effective clinical interventions, ideally through drug repositioning. This seminar will detail our current efforts to do this in both breast and T cells for multiple loci associated with risk of breast cancer, and for a single locus we have found associated with progression free survival following ovarian cancer treatment. In addition I will present an update on what was hailed as Australia’s biggest medical breakthrough in decades.
Georgia Chenevix-Trench has been at QIMR since 1986, with continued NHMRC Fellowship support since 1992. She is a Fellow of the Australian Academy of Sciences and of the Australian Academy of Health and Medical Sciences. She is the author of more than 450 peer-reviewed papers, and has been instrumental in the collection of public resources such as kConFab, the Australian consortium for research into familial breast cancer. She is the leader of the Consortium of Investigators of Modifiers of BRCA1/2, and a founding member of the Breast and Ovarian Cancer Association Consortia, which have identified almost 200 novel breast and ovarian cancer susceptibility loci since the advent of genome-wide association studies. The major focus of her current research is to determine the function of alleles associated with breast cancer risk, and to identify their target genes in breast and immune cells. However, she also likes to broaden her horizons and is currently investigating the role of genes involved in niacin metabolism in miscarriages and congenital birth defects.