- 18 October 2018
1:00 pm - 2:00 pm
Thursday 18 October 2018, 1.00 PM
Auditorium, Level 3, central Building
Iron behaving badly and the host pathogen interaction
Dr David Reid,
Lung Inflammation and Infection,
QIMR Berghofer Medical Research Institute
The successful resolution of bacterial infection in humans depends upon a robust immune response. In some human lung diseases there is a failure to clear pathogens, which results in an abnormal lung microbiome and a persistent inflammatory response locally and systemically that injures the airway and contributes to chronic ill health. The genetic condition CF is a devastating disease and classic example of the consequences of failure of immune mechanisms to clear bacterial infection from the lung, which results in organ destruction and premature death. The Lung Infection and Inflammation Laboratory studies the role of iron dysregulation in the CF lung and how this promotes infection with the predominant pathogen, Pseudomonas aeruginosa. This work is unraveling the causal factors in P. aeruginosa infection in CF and uncovering problems related to cellular iron handling and intracellular oxidative stress that may contribute directly to lung injury and infection. The goal of the research is to develop new drug strategies to improve outcomes in CF lung disease and to widen the investigation of lung iron dysregulation into other disease settings such as smoking-related COPD.
Dr David Reid studies the interaction between host immunity and bacterial infection in the lung, particularly in the genetic condition cystic fibrosis (CF), and also in smoking related COPD. He commenced at QIMR Berghofer in 2010 and established his laboratory with a NHMRC Practitioner Fellowship, and subsequently was awarded a Queensland Health Fellowship. Dr Reid is a medical graduate of St Andrews University in Scotland and was also awarded his MD from St Andrews University. He is a busy respiratory specialist and Director of the Adult Cystic Fibrosis Centre at the Prince Charles Hospital, where he is joint custodian of the DeBUG CF biobank that contains a comprehensive collection of airway and peripheral blood immune cell samples complemented by detailed clinical phenotyping. A major focus of his laboratory is on innate iron withholding as a form of nutritional defence against bacteria, and in recent times his laboratory has also explored how dysregulation of iron may directly injure the host to promote inflammation, as well as facilitate infection. The goal of Dr Reid’s research is to develop anti-infectives that target bacterial iron acquisition and to also identify biomarkers to inform on clinical status.