Leishmanization is one of the oldest forms of vaccination known to man. It involves the deliberate infection of people on unexposed areas of the body with Leishmania species that cause cutaneous lesions. These lesions resolve, infection is controlled and long-term immunity is established. This is one of the few effective ways to vaccinate against parasites. We will test whether leishmanization can protect against challenge with L. donovani, a species that causes the lethal, visceral form of disease. In addition, we will determine the immune parameters associated with disease protection and establish whether they can be generated by conventional means of vaccination.
Professor Christian Engwerda | email@example.com