Most drugs currently in use have limited ovicidal activity, a major reason for treatment failures. Ivermectin and Permethrin are neuro-inhibitors targeting molecules involved in parasite mobility, but they have no effect on the immobile egg stage with its protective shell. Eggs are laid into the stratum corneum and are separated by desquamation from the serum-containing lower epidermal layers, out of reach of host defence mechanisms and systemically administered drugs. This scenario underlines the importance of topical treatments that specifically target mite eggs.
The focus of this PhD project is to identify egg-specific drug targets, understand their biological roles, identify inhibitors and test them in vitro and in our porcine in vivo model.
Fundamental knowledge about scabies mite embryogenesis and drug(s) that prevent egg hatching, to be developed as topical agent.
- Suitable for PhD students only.