The active recruitment of regulatory T (Treg) cells within the multiple myeloma (MM) environment is reported in myeloma patients. Although Treg function predominantly to mediate local immune suppression and promote neoplastic expansion, unexpectedly in some haematological malignancies they also may provide clinical benefit. At present it is unclear whether Treg recruited into MM environment are capable of fostering or impeding myeloma growth thus influence clinical outcome of HSCT. In this project few effective agents targeting Treg growth factor (eg TGFß) or causing Treg depletion will be used to specifically target Treg population in myeloma-bearing mice after HSCT. Careful examination of recruitment and function of Treg cells and other cellular elements within the myeloma environment after HCST may uncover novel therapeutic avenues.
- Some components of this project are suitable for Honours, flexible for clinical students and entire project is suitable for PhD student.